Search on: CGMP INHIBITED CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 
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Descriptor English:   Cyclic Nucleotide Phosphodiesterases, Type 3 
Descriptor Spanish:   Fosfodiesterasas de Nucleótidos Cíclicos Tipo 3 
Descriptor Portuguese:   Nucleotídeo Cíclico Fosfodiesterase do Tipo 3 
Synonyms English:   Cyclic Nucleotide Phosphodiesterase PDE3 Family
Cyclic Nucleotide Phosphodiesterases, Type 3A
Cyclic Nucleotide Phosphodiesterases, Type 3B
Phosphodiesterase 3A
Phosphodiesterase 3B
Phosphodiesterase III
cGMP-Inhibited Cyclic Nucleotide Phosphodiesterase
cGMP-Inhibited Phosphodiesterase
Phosphodiesterase, cGMP-Inhibited
cGMP Inhibited Cyclic Nucleotide Phosphodiesterase
cGMP Inhibited Phosphodiesterase  
Tree Number:   D08.811.277.352.640.150.300
D12.644.360.008.300
D12.776.476.008.300
Definition English:   A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. 
Entry Combination - descr/qualif English:   Cyclic Nucleotide Phosphodiesterases, Type 3/antagonists & inhibitors use Phosphodiesterase 3 Inhibitors
 
History Note English:   2008(1995) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   52678 
Unique Identifier:   D054684 

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